However, Giants manager Bruce Bochy challenged and replays showed that Pence's foot reached the bag before Mark Ellis' throw reached first baseman Matt Adams.
The call was overturned, but the Giants failed to score, preserving the Cardinals' 2-0 triumph.
Chris Haft is a reporter for MLB.com. Read his blog, Haft-Baked Ideas, and follow him on Twitter at @sfgiantsbeat. This story was not subject to the approval of Major League Baseball or its clubs.