Cardinals manager Mike Matheny said Freese could barely keep his glove on following the play and called for Ryan Jackson to pinch-hit for Freese in the ninth. Daniel Descalso took over at third base in the field.
Freese was left out of the lineup Saturday, and Matheny said the club will continue to monitor Freese's wrist.
"We're going to wait and watch him do his work in the cage and see if he can get it figured out," Matheny said. "It looks better today. The trainers did a nice job of getting right on top of it. It does look better than I thought it was going to, because it looked nasty yesterday. The ball almost took his glove off on the play at third."
Matt Carpenter got the start at third base for the Cardinals on Saturday.