Chris Carpenter, Jason Isringhausen and Brad Thompson all threw simulated games in Florida, while Joel Pineiro attempted to throw off the mound before the Cardinals' 14-4 loss to the Pirates.
Recovering from Tommy John reconstructive elbow surgery, Carpenter threw 41 pitches. Cardinals general manager John Mozeliak said the ace "had good command and felt good." Thompson threw 30 pitches of his own and felt comfortable as well as showing signs of regaining arm strength.
Isringhausen threw 42 pitches, and Mozeliak said he pitched with good rhythm and tempo and is feeling better. Isringhausen went to the disabled list on May 16 with a laceration to his hand after struggling in closing situations.
Pineiro, on the other hand, had trouble throwing before Saturday's game against Pittsburgh. On the DL with a strained right groin, Pineiro attempted to throw off the mound but could not pitch pain-free.
"I can [throw in the] bullpen nice and easy," Pineiro said. "But you can't go out pitching nice and easy."
Pineiro and Cardinals manager Tony La Russa said it was too early to speculate whether Pineiro would be ready to pitch on June 5, the day he is eligible to come off the DL.
Although Mike Parisi had a rough starting debut Saturday, Mozeliak said Sunday he'd like to give the rookie another start.
If everything goes according to plan, Pineiro will throw off the mound on Monday.
Lee Hurwitz is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.