Twins starter Kyle Gibson held the Cardinals hitless until Jedd Gyorko connected for a solo homer with two outs in the fourth. It was Gyorko's second homer this spring.
"It was a 2-1 sinker right down the middle," Gibson said. "A good hitter did a good job."
Gibson was otherwise terrific, finishing five innings and not allowing another hit. In 17 1/3 spring innings, Gibson has allowed four earned runs on 15 hits.
"I felt good," he said. "Everything is getting a little bit more consistent. That's the thing I've been looking for the last couple of years; consistency, getting ahead of guys, consistency with breaking pitches getting them in the zone."
The Twins tied the game up in the sixth on an RBI single by Tommy Field.
Trevor Rosenthal, making his first start since 2012, threw two scoreless innings for the Cardinals. He scattered two hits, walked two and struck out two over the 38-pitch effort. The outing followed a 12-day layoff in which Rosenthal dealt with tightness around his right lat.
"[I] definitely wanted to throw everything," Rosenthal said afterward. "I felt like I was kind of back at ground zero from where I was to start the camp. Obviously, you want to leave healthy, but at the same time work on commanding the strike zone."
Cardinals closer Seung Hwan Oh made his first appearance since returning from the World Baseball Classic. He worked around a two-out single to finish a scoreless inning.
Cardinals Up Next: First baseman Matt Carpenter will return to the lineup on Friday and be cleared to swing the bat for the first time since March 1. Adam Wainwright will start that game for St. Louis, which will travel to Port St. Lucie to face the Mets (12:05 p.m. CT). The game can be seen on MLB.TV.