Also making the cut were right-handers Brad Thompson and Josh Kinney, while righty Jorge Sosa and lefty Chris Narveson were left off.
"The only easy choice was Narveson because of his inexperience," La Russa said. "But Sosa was a tough guy to keep off."
Of the final offensive spots, So Taguchi and John Rodriguez were included while Jose Vizcaino and Skip Schumaker were not.
"On the position player side, the hardest call would be Skip because of Jim [Edmonds'] uncertainty, and Jose Vizcaino, who's been a very good veteran playoff performer," the manager said. "But we just felt like David [Eckstein] and Jim could go."
Weaver would start Game 5: One factor in the choice to leave Reyes off the roster was that the Cardinals will use a three-man starting rotation in the Division Series. If the series goes to a fifth game, Jeff Weaver will start that contest in San Diego. Weaver would be pitching on three days' rest after taking the mound in Thursday's Game 2, also at PETCO Park.
Weaver will be pitching in front of friends and family on Thursday, including his brother, Angels right-hander Jered. The Weavers hail from Southern California.
"It's during the week, so I won't have as many people traveling," Jeff Weaver said. "But my parents and my brother and a couple friends will be making the trip down. It's always fun to be able to go out there and have those guys in the stands, people that support you throughout.
"It's a familiar environment, a comfortable environment for me. I'm just hoping all those things involved enable me to go out there and do well."
Opening lineup: With his first lineup of the postseason, La Russa went with a look that hadn't been seen in quite a while -- with Edmonds not only starting in center field, but batting fourth. None of the team's reserves made their way into the lineup, with Chris Duncan in left field and batting second, Juan Encarnacion hitting sixth and playing right field and Ronnie Belliard at second base and in the No. 7 hole.
Edmonds is still bothered by pain in his left foot, but is cleared to play.
"He took a [cortisone] shot in his toe and he felt relief," La Russa said. "I think an important part of this series is defending center field at this ballpark. So we're going to go with Jim and see how he does."
Coming up: Wednesday is a workout day, with no game in this Division Series. On Thursday, it will be a pair of veterans who changed teams during the season. David Wells will take the mound for San Diego against Weaver, with game time set for 3 p.m. CT on ESPN.